Juvederm Injectable Gel - JUVÉDERM® is a highly effective injectable dermal fillers designed to restore a more youthful appearance by restoring lost volume, smoothing out lines and wrinkles, and addressing additional signs of facial aging. JUVÉDERM® is made with synthetic hyaluronic acid (HA), a substance that also occurs naturally in the body and contributes to healthy, supple skin and the production of collagen.